Vascular Non-Inflammatory Molecule 3 (Pantetheinase VNN3)

VNN3gene

VNN3 upregulation amplifies oxidative stress and endothelial inflammation in acute MI.

Pathway placement

Cascade stepPlaque inflammation

Confidencemedium

RationalePantetheinase involved in reactive oxygen species generation and inflammatory responses.

Also acts inEndothelial activation/erosion

Druggability

Not assessed (no mapped human gene target).

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.

Specimen

Whole blood — gene is not a circulating analyte; measure protein product or genotype

Collection tube

K2-EDTA whole blood (lavender-top)

Method / principle

SNP genotyping / sequencing; or immunoassay of encoded protein

Reagent / substrate

Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein

Platform

qPCR / NGS / array

Turnaround · availability

Send-out · Genotyping widely available; protein assay variable