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von Willebrand factor
Pathway / Endothelial activation & erosion

von Willebrand factor

VWFprotein

vWF exposure following endothelial activation enables platelet adhesion and thrombotic cascade initiation.

Pathway placement
Cascade stepEndothelial activation & erosion
Confidencehigh
RationaleAnchor molecule; exposed by endothelial erosion/dysfunction; mediates platelet tethering.
Also acts inPlatelet activation
Druggability
DruggableYes
Known drugs / candidates4
Small-molecule tractableYes
Antibody tractableYes
EnsemblENSG00000110799

Type I vs Type II discrimination

ScoresShared / rises in both
R — rupture / Type-I
67
C — confounder / Type-II
61
A — assay feasibility
72
E — evidence strength
95
T1DI (composite)
36
Specificity differential (R−C)+5.6
Confounder panel (Type-II drivers)
1sepsis / systemic inflammationmag 2
2anemia / acute blood lossn/a
3hypovolemia / dehydrationmag 1
4tachyarrhythmiamag 2
5hypoxemia / respiratory failuremag 2
6hypertensive emergencymag 2
7high-demand / peri-operative stressmag 2
Coverage: 6/7 confounders with evidence
Tier: deep-scored (abstract-extracted) · 18 supporting references. See the discrimination table for all markers.

Assay & specimen

Validated clinical assay
Specimen
Platelet-poor plasma
Collection tube
Sodium citrate 3.2% (light blue-top)
Method / principle
Immunoturbidimetric (VWF:Ag) + GPIbM/ristocetin cofactor activity
Reagent / substrate
Anti-VWF latex; recombinant GPIb fragment or ristocetin+platelets
Platform
Coagulation analyzer
Turnaround · availability
Send-out · Specialized lab

Literature evidence(60)

Showing 40 of 60 linked references.