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von Willebrand factor
Pathway / Endothelial activation & erosion

von Willebrand factor

VWFprotein

vWF exposure following endothelial activation enables platelet adhesion and thrombotic cascade initiation.

Pathway placement
Cascade stepEndothelial activation & erosion
Confidencehigh
RationaleAnchor molecule; exposed by endothelial erosion/dysfunction; mediates platelet tethering.
Also acts inPlatelet activation
Druggability
DruggableYes
Known drugs / candidates4
Small-molecule tractableYes
Antibody tractableYes
EnsemblENSG00000110799

Type I vs non-Type I discrimination

ScoresShared / rises in both
R — rupture / Type-I
67
C — non-Type-I
64
A — assay feasibility
72
E — evidence strength
95
T1DI (composite)
35
Specificity differential (R−C)+3.1
Non-Type-I axis panel
Does this marker also move in each non-Type-I setting? mag 0–3; higher means less Type-I-specific. n/a = no evidence retrieved, which is not the same as no change.
2sepsis / systemic inflammationmag 2
2anemia / acute blood lossn/a
2hypovolemia / dehydrationmag 1
2tachyarrhythmiamag 2
2hypoxemia / respiratory failuremag 2
2hypertensive emergencymag 2
2high-demand / peri-operative stressmag 2
3sudden cardiac deathmag 2
4aPCI-related periproceduralmag 2
4bstent thrombosismag 2
4cin-stent restenosismag 2
5CABG-relatedmag 2
Coverage: 11/12 axes with evidence
Tier: deep-scored (abstract-extracted) · 26 supporting references. See the discrimination table for all markers.

Assay & specimen

Validated clinical assay
Specimen
Platelet-poor plasma
Collection tube
Sodium citrate 3.2% (light blue-top)
Method / principle
Immunoturbidimetric (VWF:Ag) + GPIbM/ristocetin cofactor activity
Reagent / substrate
Anti-VWF latex; recombinant GPIb fragment or ristocetin+platelets
Platform
Coagulation analyzer
Turnaround · availability
Send-out · Specialized lab

Literature evidence(60)

Showing 40 of 60 linked references.