WIPI1
WIPI1geneWIPI1 serves as an early diagnostic biomarker for acute myocardial infarction, likely reflecting autophagy-related cellular stress responses.
Pathway placement
Cascade stepOff-pathway / systemic markers
Confidencelow
RationaleEarly diagnostic biomarker; autophagy-related, off-cascade.
Druggability
Not assessed (no mapped human gene target).
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Whole blood — gene is not a circulating analyte; measure protein product or genotype
Collection tube
K2-EDTA whole blood (lavender-top)
Method / principle
SNP genotyping / sequencing; or immunoassay of encoded protein
Reagent / substrate
Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein
Platform
qPCR / NGS / array
Turnaround · availability
Send-out · Genotyping widely available; protein assay variable
Literature evidence(1)
- Pyroptosis inhibition improves the symptom of acute myocardial infarction.Cell death & disease · 2021 · PMID 34531373 · doi