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XIST
Pathway / Myocardial injury (shared endpoint)

XIST

XISTrna

XIST is a circulating long non-coding RNA elevated during acute myocardial injury and ischemia.

Pathway placement
Cascade stepMyocardial injury (shared endpoint)
Confidencelow
RationalelncRNA biomarker for acute MI; reflects acute ischemic injury response.
Druggability
DruggableNo
Known drugs / candidates0
Small-molecule tractableNo
Antibody tractableNo
EnsemblENSG00000229807

Type I vs non-Type I discrimination

ScoresLow-confidence (proxy)
R — rupture / Type-I
26
C — non-Type-I
57
A — assay feasibility
50
E — evidence strength
21
T1DI (composite)
4
Specificity differential (R−C)-31.1
Non-Type-I axis panel
Does this marker also move in each non-Type-I setting? mag 0–3; higher means less Type-I-specific. n/a = no evidence retrieved, which is not the same as no change.
No non-Type-I axis evidence retrieved.
Tier: light (literature co-occurrence proxy — lower confidence). See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Whole blood (transcript)
Collection tube
PAXgene/Tempus RNA tube · K2/K3-EDTA (lavender-top)
Method / principle
RT-qPCR (TaqMan) or small-RNA sequencing
Reagent / substrate
Target-specific primers/probe; reverse transcriptase (miRNA: stem-loop RT primer)
Platform
qPCR instrument / NGS
Turnaround · availability
Research / send-out · Research (few LDTs)

Literature evidence(1)