Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Zeta

YWHAZprotein

YWHAZ (14-3-3-zeta) is a cardioprotective adaptor protein whose downregulation in acute MI reflects early cardiomyocyte injury and ischemic stress.

Pathway placement

Cascade stepMyocardial injury (shared endpoint)

Confidencehigh

RationaleEarly AMI injury marker; downregulated in STEMI; cardioprotection target.

Also acts inPlatelet activation, Endothelial activation/erosion

Druggability

DruggableYes

Known drugs / candidates0

Small-molecule tractableYes

Antibody tractableNo

EnsemblENSG00000164924

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.

Specimen

Serum or plasma

Collection tube

Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)

Method / principle

Sandwich immunoassay (ELISA) — research-grade unless a cleared assay exists

Reagent / substrate

Matched anti-target antibody pair (capture + labeled detection)

Platform

ELISA microplate or multiplex (Luminex/MSD)

Turnaround · availability

Send-out / research · Research-grade (no universal clinical assay)