Zinc Finger CCHC-Type Containing 1
ZC3HC1proteinZC3HC1 variants associate with blood pressure regulation and stroke risk.
Pathway placement
Cascade stepOff-pathway / systemic markers
Confidencelow
RationaleBlood pressure and stroke susceptibility locus; pleiotropic cardiovascular risk.
Druggability
DruggableNo
Known drugs / candidates0
Small-molecule tractableNo
Antibody tractableNo
EnsemblENSG00000091732
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)
Method / principle
Sandwich immunoassay (ELISA) — research-grade unless a cleared assay exists
Reagent / substrate
Matched anti-target antibody pair (capture + labeled detection)
Platform
ELISA microplate or multiplex (Luminex/MSD)
Turnaround · availability
Send-out / research · Research-grade (no universal clinical assay)
Human genetic evidence
0.515
Open Targets association (myocardial_infarction)
5
GWAS associations
Traits: myocardial infarction
Literature evidence(1)
- Identification of Phosphorylation Associated SNPs for Blood Pressure, Coronary Artery Disease and Stroke from Genome-wide Association Studies.Current molecular medicine · 2019 · PMID 31456518 · doi