12,13-dihydroxy-octadecenoic acid

metabolite

12,13-diHOME is an oxidized polyunsaturated fatty acid metabolite reflecting systemic lipid peroxidation and vascular inflammation in acute coronary syndromes.

Pathway placement

Cascade stepPlaque inflammation

Confidencemedium

RationaleOxidized linoleic acid metabolite; marker of lipid peroxidation and inflammation.

Also acts inLipid entry/oxidation

Druggability

Not assessed (no mapped human gene target).

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.

Specimen

Serum, plasma or urine

Collection tube

Serum separator (gold/red-top, SST) · Lithium heparin (green-top) · Sterile urine container

Method / principle

LC-MS/MS (targeted metabolomics) or enzymatic colorimetric where available

Reagent / substrate

Stable-isotope-labeled internal standard (MS); or enzyme-coupled Trinder reagent

Platform

LC-MS/MS; some automated chemistry

Turnaround · availability

Send-out / research · Specialized / research

Literature evidence(1)

12,13-diHOME and noradrenaline are associated with the occurrence of acute myocardial infarction in patients with type 2 diabetes mellitus.
Diabetology & metabolic syndrome · 2023 · PMID 37386486 · doi