16,17-EDP
metabolite16,17-EDP, derived from omega-3 PUFA, restrains platelet activation and leukocyte recruitment.
Pathway placement
Cascade stepPlaque inflammation
Confidencemedium
RationaleDocosahexaenoic acid epoxide; specialized mediator reducing platelet and inflammatory responses.
Also acts inPlatelet activation
Druggability
Not assessed (no mapped human gene target).
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum, plasma or urine
Collection tube
Serum separator (gold/red-top, SST) · Lithium heparin (green-top) · Sterile urine container
Method / principle
LC-MS/MS (targeted metabolomics) or enzymatic colorimetric where available
Reagent / substrate
Stable-isotope-labeled internal standard (MS); or enzyme-coupled Trinder reagent
Platform
LC-MS/MS; some automated chemistry
Turnaround · availability
Send-out / research · Specialized / research
Literature evidence(1)
- Omega-3 polyunsaturated fatty acid supplementation improves lipid metabolism and endothelial function by providing a beneficial eicosanoid-pattern in patients with acute myocardial infarction: A randomized, controlled trial.Clinical nutrition (Edinburgh, Scotland) · 2020 · PMID 33041091 · doi