5-oxo-D-proline
metabolite5-oxo-D-proline is a circulating metabolite elevated in acute coronary syndrome with plausible links to oxidative stress during acute myocardial injury.
Pathway placement
Cascade stepOff-pathway / systemic markers
Confidencelow
RationaleMetabolite associated with acute coronary syndrome; axis between oxidative stress and injury.
Also acts inMyocardial injury
Druggability
Not assessed (no mapped human gene target).
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum, plasma or urine
Collection tube
Serum separator (gold/red-top, SST) · Lithium heparin (green-top) · Sterile urine container
Method / principle
LC-MS/MS (targeted metabolomics) or enzymatic colorimetric where available
Reagent / substrate
Stable-isotope-labeled internal standard (MS); or enzyme-coupled Trinder reagent
Platform
LC-MS/MS; some automated chemistry
Turnaround · availability
Send-out / research · Specialized / research
Literature evidence(1)
- Plasma Metabolomics of Acute Coronary Syndrome Patients Based on Untargeted Liquid Chromatography-Mass Spectrometry.Frontiers in cardiovascular medicine · 2021 · PMID 34095243 · doi