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8-iso-PGF2α
Pathway / Lipid retention & oxidation

8-iso-PGF2α

metabolite

8-iso-PGF2α quantifies free-radical-driven lipid peroxidation in atherogenic lipoprotein oxidation and plaque destabilization.

Pathway placement
Cascade stepLipid retention & oxidation
Confidencehigh
RationaleF2-isoprostane marker of lipid peroxidation; reflects oxidative damage in atherosclerotic plaque.
Also acts inVascular inflammation
Druggability
Not assessed (no mapped human gene target).

Type I vs non-Type I discrimination

ScoresLow-confidence (proxy)
R — rupture / Type-I
39
C — non-Type-I
54
A — assay feasibility
42
E — evidence strength
22
T1DI (composite)
4
Specificity differential (R−C)-15.1
Non-Type-I axis panel
Does this marker also move in each non-Type-I setting? mag 0–3; higher means less Type-I-specific. n/a = no evidence retrieved, which is not the same as no change.
No non-Type-I axis evidence retrieved.
Tier: light (literature co-occurrence proxy — lower confidence). See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum, plasma or urine
Collection tube
Serum separator (gold/red-top, SST) · Lithium heparin (green-top) · Sterile urine container
Method / principle
LC-MS/MS (targeted metabolomics) or enzymatic colorimetric where available
Reagent / substrate
Stable-isotope-labeled internal standard (MS); or enzyme-coupled Trinder reagent
Platform
LC-MS/MS; some automated chemistry
Turnaround · availability
Send-out / research · Specialized / research

Literature evidence(1)