Aldosterone
metaboliteAldosterone promotes vascular inflammation, endothelial dysfunction, and atherosclerotic plaque progression through mineralocorticoid-receptor signaling.
Pathway placement
Cascade stepPlaque inflammation
Confidencemedium
RationalePro-atherosclerotic hormone; drives plaque inflammation and atherosclerotic burden.
Also acts inLipid entry/oxidation
Druggability
Not assessed (no mapped human gene target).
Type I vs non-Type I discrimination
ScoresNon-Type-I-associated
R — rupture / Type-I—
C — non-Type-I58
A — assay feasibility42
E — evidence strength52
T1DI (composite)6
Specificity differential (R−C)-43.3
Non-Type-I axis panel
Does this marker also move in each non-Type-I setting? mag 0–3; higher means less Type-I-specific. n/a = no evidence retrieved, which is not the same as no change.
2sepsis / systemic inflammationmag 2
2anemia / acute blood lossn/a
2hypovolemia / dehydrationmag 2
2tachyarrhythmiamag 1
2hypoxemia / respiratory failuremag 1
2hypertensive emergencymag 3
2high-demand / peri-operative stressn/a
3sudden cardiac deathmag 1
4aPCI-related periproceduraln/a
4bstent thrombosisn/a
4cin-stent restenosismag 2
5CABG-relatedmag 2
Coverage: 8/12 axes with evidence
Tier: deep-scored (abstract-extracted) · 18 supporting references. See the discrimination table for all markers.
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum, plasma or urine
Collection tube
Serum separator (gold/red-top, SST) · Lithium heparin (green-top) · Sterile urine container
Method / principle
LC-MS/MS (targeted metabolomics) or enzymatic colorimetric where available
Reagent / substrate
Stable-isotope-labeled internal standard (MS); or enzyme-coupled Trinder reagent
Platform
LC-MS/MS; some automated chemistry
Turnaround · availability
Send-out / research · Specialized / research
Literature evidence(4)
- Vasculometabolic and Inflammatory Effects of Aldosterone in Obesity.The Journal of clinical endocrinology and metabolism · 2020 · PMID 32529242 · doi
- Aldosterone increases early atherosclerosis and promotes plaque inflammation through a placental growth factor-dependent mechanism.Journal of the American Heart Association · 2013 · PMID 23525413 · doi
- Aldosterone, atherosclerosis and vascular events in patients with stable coronary artery disease.International journal of cardiology · 2012 · PMID 22727970 · doi
- Biomarkers in the early period of acute myocardial infarction in rat serum and protective effects of Shexiang Baoxin Pill using a metabolomic method.Journal of ethnopharmacology · 2011 · PMID 22001859 · doi