CoronaryAtlas logo
CoronaryAtlas
Apolipoprotein C
Pathway / Lipid retention & oxidation

Apolipoprotein C

lipoprotein

Apolipoprotein C mediates lipid metabolism and HDL remodeling; its altered expression during plaque rupture and coronary events reflects changes in lipoprotein turnover.

Pathway placement
Cascade stepLipid retention & oxidation
Confidencemedium
RationaleHDL apolipoprotein; altered in plaque rupture; lipid-metabolism marker.
Also acts inVascular inflammation
Druggability
Not assessed (no mapped human gene target).

Type I vs non-Type I discrimination

ScoresLow-confidence (proxy)
R — rupture / Type-I
46
C — non-Type-I
50
A — assay feasibility
82
E — evidence strength
21
T1DI (composite)
8
Specificity differential (R−C)-3.8
Non-Type-I axis panel
Does this marker also move in each non-Type-I setting? mag 0–3; higher means less Type-I-specific. n/a = no evidence retrieved, which is not the same as no change.
No non-Type-I axis evidence retrieved.
Tier: light (literature co-occurrence proxy — lower confidence). See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST)
Method / principle
Immunoturbidimetric/nephelometric; or NMR/ultracentrifugation for subfractions
Reagent / substrate
Anti-apolipoprotein antibody-latex; or NMR profile
Platform
Automated analyzer / NMR
Turnaround · availability
Routine–send-out · Variable

Literature evidence(2)