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C-terminal agrin fragment
Pathway / Myocardial injury (shared endpoint)

C-terminal agrin fragment

peptide

A proteolytic agrin fragment that marks myocardial necrosis and predicts post-infarction acute kidney injury through systemic inflammatory and ischemic stress pathways.

Pathway placement
Cascade stepMyocardial injury (shared endpoint)
Confidencemedium
RationaleProteolytic agrin fragment released during myocardial injury; predicts acute kidney injury post-AMI.
Also acts inSystemic / off-pathway
Druggability
Not assessed (no mapped human gene target).

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Plasma (EDTA; peptidase-labile — chilled + protease inhibitor)
Collection tube
K2-EDTA, chilled plastic (lavender-top) · Serum separator (gold/red-top, SST)
Method / principle
Competitive/sandwich immunoassay or LC-MS/MS
Reagent / substrate
Anti-peptide antibody; or isotope-labeled internal standard (MS)
Platform
Immunoassay / LC-MS/MS
Turnaround · availability
Send-out / research · Research-grade

Literature evidence(1)