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CD31
Pathway / Endothelial activation & erosion

CD31

protein

CD31 marks endothelial cell activation and erosion in sEVs, indicating endothelial dysfunction and superficial erosion in Type 1 MI pathology.

Pathway placement
Cascade stepEndothelial activation & erosion
Confidencemedium
RationaleEndothelial marker in sEVs; signals endothelial cell damage and erosion.
Druggability
Not assessed (no mapped human gene target).

Type I vs Type II discrimination

ScoresIndeterminate
R — rupture / Type-I
—
C — confounder / Type-II
27
A — assay feasibility
68
E — evidence strength
42
T1DI (composite)
13
Specificity differential (R−C)-11.7
Confounder panel (Type-II drivers)
1sepsis / systemic inflammationmag 0
2anemia / acute blood lossn/a
3hypovolemia / dehydrationmag 0
4tachyarrhythmian/a
5hypoxemia / respiratory failuremag 2
6hypertensive emergencymag 0
7high-demand / peri-operative stressmag 2
Coverage: 5/7 confounders with evidence
Tier: deep-scored (abstract-extracted) · 14 supporting references. See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)
Method / principle
Sandwich immunoassay (ELISA) — research-grade unless a cleared assay exists
Reagent / substrate
Matched anti-target antibody pair (capture + labeled detection)
Platform
ELISA microplate or multiplex (Luminex/MSD)
Turnaround · availability
Send-out / research · Research-grade (no universal clinical assay)

Literature evidence(19)