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CD31
Pathway / Endothelial activation & erosion

CD31

protein

CD31 marks endothelial cell activation and erosion in sEVs, indicating endothelial dysfunction and superficial erosion in Type 1 MI pathology.

Pathway placement
Cascade stepEndothelial activation & erosion
Confidencemedium
RationaleEndothelial marker in sEVs; signals endothelial cell damage and erosion.
Druggability
Not assessed (no mapped human gene target).

Type I vs non-Type I discrimination

ScoresIndeterminate
R — rupture / Type-I
—
C — non-Type-I
41
A — assay feasibility
68
E — evidence strength
42
T1DI (composite)
11
Specificity differential (R−C)-25.7
Non-Type-I axis panel
Does this marker also move in each non-Type-I setting? mag 0–3; higher means less Type-I-specific. n/a = no evidence retrieved, which is not the same as no change.
2sepsis / systemic inflammationmag 0
2anemia / acute blood lossn/a
2hypovolemia / dehydrationmag 0
2tachyarrhythmian/a
2hypoxemia / respiratory failuremag 2
2hypertensive emergencymag 0
2high-demand / peri-operative stressmag 2
3sudden cardiac deathn/a
4aPCI-related periproceduralmag 2
4bstent thrombosismag 1
4cin-stent restenosismag 2
5CABG-relatedmag 2
Coverage: 9/12 axes with evidence
Tier: deep-scored (abstract-extracted) · 20 supporting references. See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)
Method / principle
Sandwich immunoassay (ELISA) — research-grade unless a cleared assay exists
Reagent / substrate
Matched anti-target antibody pair (capture + labeled detection)
Platform
ELISA microplate or multiplex (Luminex/MSD)
Turnaround · availability
Send-out / research · Research-grade (no universal clinical assay)

Literature evidence(19)