CD34
proteinCirculating CD34+ endothelial progenitor and endothelial cells mark endothelial erosion and reparative responses in MI.
Pathway placement
Cascade stepEndothelial activation & erosion
Confidencemedium
RationaleEndothelial progenitor/cell marker; erosion detection, post-MI angiogenesis.
Also acts inMyocardial injury
Druggability
Not assessed (no mapped human gene target).
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)
Method / principle
Sandwich immunoassay (ELISA) — research-grade unless a cleared assay exists
Reagent / substrate
Matched anti-target antibody pair (capture + labeled detection)
Platform
ELISA microplate or multiplex (Luminex/MSD)
Turnaround · availability
Send-out / research · Research-grade (no universal clinical assay)
Literature evidence(12)
- Circulating microparticle concentrations across acute and chronic cardiovascular disease conditions.Physiological reports · 2020 · PMID 32748505 · doi
- Circulating Endothelial Cells and Endothelial Function Predict Major Adverse Cardiac Events and Early Adverse Left Ventricular Remodeling in Patients With ST-Segment Elevation Myocardial Infarction.Journal of interventional cardiology · 2016 · PMID 26864952 · doi
- Co-expression of vascular and lymphatic endothelial cell markers on early endothelial cells present in aspirated coronary thrombi from patients with ST-elevation myocardial infarction.Experimental and molecular pathology · 2015 · PMID 26657000 · doi
- Coronary thrombi neovascularization in patients with ST-elevation myocardial infarction - clinical and angiographic implications.Thrombosis research · 2014 · PMID 25262107 · doi
- Endothelial progenitor cells, atheroma burden and clinical outcome in patients with coronary artery disease.Heart (British Cardiac Society) · 2013 · PMID 23390050 · doi
- Effects of EPC capture stent and CD34+ mobilization in acute myocardial infarction.Minerva cardioangiologica · 2013 · PMID 23492604
- Endothelial progenitor cells in acute myocardial infarction and sleep-disordered breathing.American journal of respiratory and critical care medicine · 2012 · PMID 23155141 · doi
- Circulating progenitor cells in stable coronary heart disease and acute coronary syndromes: relevant reparatory mechanism?Heart (British Cardiac Society) · 2007 · PMID 17395668 · doi
- Improved identification of endothelial erosion by simultaneous detection of endothelial cells (CD31/CD34) and platelets (CD42b).Endothelium : journal of endothelial cell research · 2007 · PMID 17497364 · doi
- The impact of the capability of circulating progenitor cell to differentiate on myocardial salvage in patients with primary acute myocardial infarction.Circulation · 2006 · PMID 16820559 · doi
- Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells.The Journal of clinical investigation · 2001 · PMID 11390421 · doi
- Mobilization of endothelial progenitor cells in patients with acute myocardial infarction.Circulation · 2001 · PMID 11401930 · doi
Omics datasets(1)
- E-MTAB-13508ArrayExpressPopulation RNA Seq of human HSPCs (Lineage negative, CD38 negative, CD34 positive) of control patients or myocardial infarction patients and treated with at-RA/