Cholylvaline
metaboliteBile acid-amino acid conjugate reflecting perturbed hepatic lipid metabolism and systemic response to myocardial injury.
Pathway placement
Cascade stepOff-pathway / systemic markers
Confidencemedium
RationaleSecondary bile acid conjugate reflecting altered bile acid metabolism; systemic metabolic marker of MI response.
Also acts inLipid entry/oxidation
Druggability
Not assessed (no mapped human gene target).
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum, plasma or urine
Collection tube
Serum separator (gold/red-top, SST) · Lithium heparin (green-top) · Sterile urine container
Method / principle
LC-MS/MS (targeted metabolomics) or enzymatic colorimetric where available
Reagent / substrate
Stable-isotope-labeled internal standard (MS); or enzyme-coupled Trinder reagent
Platform
LC-MS/MS; some automated chemistry
Turnaround · availability
Send-out / research · Specialized / research
Literature evidence(1)
- Acute myocardial infarction induces sex-specific, time-dependent remodeling of the gut microbiome and intestinal immune compartment in retired breeder C57BL/6N mice.Frontiers in microbiomes · 2026 · PMID 42338577 · doi