circMap4k2
rnaCircMap4k2 regulates cardiac repair processes and reduces myocardial remodeling following ischemic injury.
Pathway placement
Cascade stepMyocardial injury (shared endpoint)
Confidencemedium
RationaleCircular RNA mediating cardiac repair and remodeling post-MI; operates at cardiomyocyte-injury endpoint.
Druggability
Not assessed (no mapped human gene target).
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Whole blood or cell-free plasma
Collection tube
PAXgene/Tempus RNA tube · K2/K3-EDTA (lavender-top)
Method / principle
RT-qPCR (TaqMan) or small-RNA sequencing
Reagent / substrate
Target-specific primers/probe; reverse transcriptase (miRNA: stem-loop RT primer)
Platform
qPCR instrument / NGS
Turnaround · availability
Research / send-out · Research (few LDTs)
Literature evidence(1)
- LCZ696 (sacubitril/valsartan mixture) promotes cardiac repair and reverses residual remodelling of surgical ventricular reconstruction in post-myocardial infarction mice by targeting circMap4k2/LIN28A/PDK1 pathway.British journal of pharmacology · 2026 · PMID 41527427 · doi