D-Fructose
metaboliteD-Fructose is a carbohydrate metabolite associated with coronary artery disease via systemic metabolic dysregulation and glucose homeostasis.
Pathway placement
Cascade stepOff-pathway / systemic markers
Confidencelow
RationaleCarbohydrate; systemic metabolic marker; off-pathway metabolic risk.
Druggability
Not assessed (no mapped human gene target).
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum, plasma or urine
Collection tube
Serum separator (gold/red-top, SST) · Lithium heparin (green-top) · Sterile urine container
Method / principle
LC-MS/MS (targeted metabolomics) or enzymatic colorimetric where available
Reagent / substrate
Stable-isotope-labeled internal standard (MS); or enzyme-coupled Trinder reagent
Platform
LC-MS/MS; some automated chemistry
Turnaround · availability
Send-out / research · Specialized / research
Literature evidence(1)
- Plasma Metabolic Profiling and Multiclass Diagnostic Model Development for Stable Angina Pectoris and Acute Myocardial Infarction.ACS omega · 2024 · PMID 38617635 · doi