Desialylated LDL
lipoproteinDesialylated LDL is a glycosylation-modified form with reduced clearance and enhanced atherogenic lipoprotein retention in the arterial intima and immune activation.
Pathway placement
Cascade stepLipid retention & oxidation
Confidencehigh
RationaleAtherogenic LDL modification; retained in intima with high immune affinity.
Also acts inVascular inflammation
Druggability
Not assessed (no mapped human gene target).
Assay & specimen
Specialized reference method
Specimen
Serum or plasma (EDTA)
Collection tube
K2/K3-EDTA (lavender-top) · Serum separator (gold/red-top, SST)
Method / principle
Sandwich ELISA against the modified-apoB neoepitope
Reagent / substrate
Anti-modified-LDL monoclonal capture + anti-apoB detection
Platform
ELISA plate
Turnaround · availability
Research · Research/CE
Literature evidence(2)
- Desialylated vs. Oxidized LDL: Sialidase Inhibitors as Promising Antiatherosclerotic Agents.Current atherosclerosis reports · 2026 · PMID 42189392 · doi
- We Must Abandon the Myth: Oxidized Low-density Lipoprotein is not a Lipoprotein that Plays a Key Role in Atherogenesis.Current medicinal chemistry · 2025 · PMID 38494931 · doi