Diacylglycerols
lipidElevated diacylglycerols in atherosclerotic plaque and thrombus influence lipid-mediated inflammation and platelet activation.
Pathway placement
Cascade stepLipid retention & oxidation
Confidencemedium
RationalePlaque and thrombus lipid composition; altered with cardiovascular environmental stressors.
Also acts inThromboxane / COX-1, Coagulation / thrombus
Druggability
Not assessed (no mapped human gene target).
Type I vs Type II discrimination
ScoresLow-confidence (proxy)
R — rupture / Type-I28
C — confounder / Type-II45
A — assay feasibility40
E — evidence strength18
T1DI (composite)3
Specificity differential (R−C)-17.2
Confounder panel (Type-II drivers)
No confounder evidence retrieved.
Tier: light (literature co-occurrence proxy — lower confidence). See the discrimination table for all markers.
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum or plasma (EDTA to limit oxidation)
Collection tube
K2/K3-EDTA (lavender-top) · Serum separator (gold/red-top, SST)
Method / principle
LC-MS/MS lipidomics (targeted or shotgun)
Reagent / substrate
Deuterated lipid-class internal standards; MS/MS transitions
Platform
LC-MS/MS
Turnaround · availability
Research · Research-only
Literature evidence(2)
- Elucidating stroke etiology through lipidomics of thrombi and plasma in acute ischemic stroke patients undergoing endovascular thrombectomy.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2025 · PMID 40322967 · doi
- Human serum lipidomics analysis revealed glyphosate may lead to lipid metabolism disorders and health risks.Environment international · 2022 · PMID 36495677 · doi