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Docosahexaenoic acid
Pathway / Lipid retention & oxidation

Docosahexaenoic acid

lipid

Docosahexaenoic acid, an omega-3 polyunsaturated fatty acid, accumulates differentially in stable versus rupture-prone atherosclerotic plaques and correlates with endothelial erosion.

Pathway placement
Cascade stepLipid retention & oxidation
Confidencemedium
RationaleOmega-3 PUFA with plaque-stabilizing properties; differentiates erosion from rupture phenotypes.
Also acts inEndothelial activation/erosion
Druggability
Not assessed (no mapped human gene target).

Type I vs Type II discrimination

ScoresLow-confidence (proxy)
R — rupture / Type-I
68
C — confounder / Type-II
86
A — assay feasibility
40
E — evidence strength
33
T1DI (composite)
5
Specificity differential (R−C)-18.7
Confounder panel (Type-II drivers)
No confounder evidence retrieved.
Tier: light (literature co-occurrence proxy — lower confidence). See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum or plasma (EDTA to limit oxidation)
Collection tube
K2/K3-EDTA (lavender-top) · Serum separator (gold/red-top, SST)
Method / principle
LC-MS/MS lipidomics (targeted or shotgun)
Reagent / substrate
Deuterated lipid-class internal standards; MS/MS transitions
Platform
LC-MS/MS
Turnaround · availability
Research · Research-only

Literature evidence(3)