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epoxyeicosatrienoic acids
Pathway / Myocardial injury (shared endpoint)

epoxyeicosatrienoic acids

lipid

Epoxyeicosatrienoic acids are cardioprotective lipid mediators derived from arachidonic acid that promote myocardial repair and inflammation resolution.

Pathway placement
Cascade stepMyocardial injury (shared endpoint)
Confidencemedium
RationaleCytoprotective eicosanoid; cardioprotection and resolution of cardiac inflammation during myocardial healing.
Also acts inVascular inflammation
Druggability
Not assessed (no mapped human gene target).

Type I vs Type II discrimination

ScoresLow-confidence (proxy)
R — rupture / Type-I
33
C — confounder / Type-II
68
A — assay feasibility
40
E — evidence strength
25
T1DI (composite)
3
Specificity differential (R−C)-35.1
Confounder panel (Type-II drivers)
No confounder evidence retrieved.
Tier: light (literature co-occurrence proxy — lower confidence). See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum or plasma (EDTA to limit oxidation)
Collection tube
K2/K3-EDTA (lavender-top) · Serum separator (gold/red-top, SST)
Method / principle
LC-MS/MS lipidomics (targeted or shotgun)
Reagent / substrate
Deuterated lipid-class internal standards; MS/MS transitions
Platform
LC-MS/MS
Turnaround · availability
Research · Research-only

Literature evidence(2)