Esterified hydroxyeicosatetraenoic acids

lipid

Esterified oxidized eicosanoid metabolites generated during plaque inflammation that characterize vulnerable, symptomatic atherosclerotic lesions.

Pathway placement

Cascade stepPlaque inflammation

Confidencehigh

RationaleOxidized eicosanoid metabolites implicated in plaque inflammation and rupture-prone phenotype.

Also acts inLipid entry/oxidation

Druggability

Not assessed (no mapped human gene target).

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.

Specimen

Serum or plasma (EDTA to limit oxidation)

Collection tube

K2/K3-EDTA (lavender-top) · Serum separator (gold/red-top, SST)

Method / principle

LC-MS/MS lipidomics (targeted or shotgun)

Reagent / substrate

Deuterated lipid-class internal standards; MS/MS transitions

Platform

LC-MS/MS

Turnaround · availability

Research · Research-only