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Fatty acids
Pathway / Lipid retention & oxidation

Fatty acids

lipid

Fatty acid composition and metabolism influence lipoprotein atherogenicity and vascular endothelial function in atherothrombotic disease.

Pathway placement
Cascade stepLipid retention & oxidation
Confidencemedium
RationaleLipid remodeling and vascular dysfunction; component of atherogenic lipidome.
Druggability
Not assessed (no mapped human gene target).

Type I vs Type II discrimination

ScoresType-II-associated
R — rupture / Type-I
—
C — confounder / Type-II
50
A — assay feasibility
40
E — evidence strength
57
T1DI (composite)
7
Specificity differential (R−C)-35
Confounder panel (Type-II drivers)
1sepsis / systemic inflammationmag 2
2anemia / acute blood lossn/a
3hypovolemia / dehydrationn/a
4tachyarrhythmiamag 1
5hypoxemia / respiratory failuremag 2
6hypertensive emergencymag 1
7high-demand / peri-operative stressn/a
Coverage: 4/7 confounders with evidence
Tier: deep-scored (abstract-extracted) · 12 supporting references. See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum or plasma (EDTA to limit oxidation)
Collection tube
K2/K3-EDTA (lavender-top) · Serum separator (gold/red-top, SST)
Method / principle
LC-MS/MS lipidomics (targeted or shotgun)
Reagent / substrate
Deuterated lipid-class internal standards; MS/MS transitions
Platform
LC-MS/MS
Turnaround · availability
Research · Research-only

Literature evidence(4)

Clinical trials(6)