GlycA
metaboliteGlycA is a glycoprotein-bound inflammation marker that correlates with monocyte recruitment and plaque destabilization in Type 1 MI pathogenesis.
Pathway placement
Cascade stepPlaque inflammation
Confidencehigh
RationaleGlycoprotein inflammation marker; reflects systemic inflammatory status in plaque destabilization.
Druggability
Not assessed (no mapped human gene target).
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum, plasma or urine
Collection tube
Serum separator (gold/red-top, SST) · Lithium heparin (green-top) · Sterile urine container
Method / principle
LC-MS/MS (targeted metabolomics) or enzymatic colorimetric where available
Reagent / substrate
Stable-isotope-labeled internal standard (MS); or enzyme-coupled Trinder reagent
Platform
LC-MS/MS; some automated chemistry
Turnaround · availability
Send-out / research · Specialized / research
Literature evidence(3)
- Greater alterations in atherogenic lipids and inflammatory markers in women during type 2 diabetes development and risk of coronary heart disease-Findings from two population-based studies.Journal of clinical lipidology · 2025 · PMID 40967996 · doi
- Early life infection and proinflammatory, atherogenic metabolomic and lipidomic profiles in infancy: a population-based cohort study.eLife · 2022 · PMID 35535496 · doi
- Lipids, Lipoproteins, and Metabolites and Risk of Myocardial Infarction and Stroke.Journal of the American College of Cardiology · 2018 · PMID 29420958 · doi