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HDL
Pathway / Lipid retention & oxidation

HDL

lipoprotein

HDL exerts atheroprotective effects via reverse cholesterol transport, antioxidant activity, and endothelial stabilization.

Pathway placement
Cascade stepLipid retention & oxidation
Confidencemedium
RationaleAnti-atherogenic; mitigates lipid retention and inflammation; endothelial protection.
Also acts inVascular inflammation, Endothelial activation/erosion
Druggability
Not assessed (no mapped human gene target).

Type I vs non-Type I discrimination

ScoresIndeterminate
R — rupture / Type-I
67
C — non-Type-I
33
A — assay feasibility
84
E — evidence strength
55
T1DI (composite)
31
Specificity differential (R−C)+33.4
Non-Type-I axis panel
Does this marker also move in each non-Type-I setting? mag 0–3; higher means less Type-I-specific. n/a = no evidence retrieved, which is not the same as no change.
2sepsis / systemic inflammationn/a
2anemia / acute blood lossn/a
2hypovolemia / dehydrationn/a
2tachyarrhythmian/a
2hypoxemia / respiratory failuren/a
2hypertensive emergencyn/a
2high-demand / peri-operative stressn/a
3sudden cardiac deathmag 1
4aPCI-related periproceduraln/a
4bstent thrombosismag 1
4cin-stent restenosismag 1
5CABG-relatedn/a
Coverage: 3/12 axes with evidence
Tier: deep-scored (abstract-extracted) · 5 supporting references. See the discrimination table for all markers.

Assay & specimen

Validated clinical assay
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST) · Lithium heparin (green-top)
Method / principle
Direct enzymatic (homogeneous)
Reagent / substrate
Selective detergent + cholesterol esterase/oxidase/peroxidase Trinder
Platform
Automated analyzer
Turnaround · availability
Routine · Universal

Literature evidence(60)

Showing 40 of 60 linked references.