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HDL-1 (large HDL)
Pathway / Lipid retention & oxidation

HDL-1 (large HDL)

lipoprotein

Large HDL particles mediate reverse cholesterol transport and protect against lipid retention and atherosclerosis progression.

Pathway placement
Cascade stepLipid retention & oxidation
Confidencehigh
RationaleLarge HDL protects; inverse association with atherosclerosis.
Druggability
Not assessed (no mapped human gene target).

Type I vs Type II discrimination

ScoresLow-confidence (proxy)
R — rupture / Type-I
23
C — confounder / Type-II
36
A — assay feasibility
82
E — evidence strength
15
T1DI (composite)
5
Specificity differential (R−C)-12.7
Confounder panel (Type-II drivers)
No confounder evidence retrieved.
Tier: light (literature co-occurrence proxy — lower confidence). See the discrimination table for all markers.

Assay & specimen

Specialized reference method
Specimen
Serum or plasma (EDTA)
Collection tube
K2/K3-EDTA (lavender-top) · Serum separator (gold/red-top, SST)
Method / principle
NMR lipoprotein particle analysis or density-gradient ultracentrifugation
Reagent / substrate
No chemical reagent — NMR spectral deconvolution of lipid methyl signals (or ultracentrifugal separation by density)
Platform
NMR (LabCorp NMR LipoProfile) / analytical ultracentrifuge
Turnaround · availability
Send-out · Specialized reference lab

Literature evidence(1)