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HDL cholesterol
Pathway / Lipid retention & oxidation

HDL cholesterol

lipoprotein

HDL removes cholesterol and phospholipid hydroperoxides from lesions, opposing atherosclerotic lipid accumulation.

Pathway placement
Cascade stepLipid retention & oxidation
Confidencehigh
RationaleCardioprotective lipoprotein opposing LDL atherogenesis.
Druggability
Not assessed (no mapped human gene target).

Type I vs Type II discrimination

ScoresIndeterminate
R — rupture / Type-I
33
C — confounder / Type-II
33
A — assay feasibility
84
E — evidence strength
57
T1DI (composite)
24
Specificity differential (R−C)0
Confounder panel (Type-II drivers)
1sepsis / systemic inflammationmag 1
2anemia / acute blood lossn/a
3hypovolemia / dehydrationn/a
4tachyarrhythmiamag 1
5hypoxemia / respiratory failuremag 1
6hypertensive emergencyn/a
7high-demand / peri-operative stressn/a
Coverage: 3/7 confounders with evidence
Tier: deep-scored (abstract-extracted) · 5 supporting references. See the discrimination table for all markers.

Assay & specimen

Validated clinical assay
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST) · Lithium heparin (green-top)
Method / principle
Direct enzymatic (homogeneous)
Reagent / substrate
Selective detergent + cholesterol esterase/oxidase/peroxidase Trinder
Platform
Automated analyzer
Turnaround · availability
Routine · Universal

Literature evidence(16)

Clinical trials(1)