HDL Particle Number

lipoprotein

HDL particle number predicts cardiovascular event risk through reverse cholesterol transport efficiency.

Pathway placement

Cascade stepLipid retention & oxidation

Confidencemedium

RationaleHDL particle concentration reflects reverse cholesterol transport capacity.

Druggability

Not assessed (no mapped human gene target).

Assay & specimen

Specialized reference method

Specimen

Serum or plasma (EDTA)

Collection tube

K2/K3-EDTA (lavender-top) · Serum separator (gold/red-top, SST)

Method / principle

NMR lipoprotein particle analysis or density-gradient ultracentrifugation

Reagent / substrate

No chemical reagent — NMR spectral deconvolution of lipid methyl signals (or ultracentrifugal separation by density)

Platform

NMR (LabCorp NMR LipoProfile) / analytical ultracentrifuge

Turnaround · availability

Send-out · Specialized reference lab

Role of HDL in those with diabetes.
Current cardiology reports · 2014 · PMID 25199216