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Intermediate-density lipoprotein
Pathway / Lipid retention & oxidation

Intermediate-density lipoprotein

lipoprotein

IDL is retained in the arterial intima and undergoes oxidative modification, seeding atherosclerotic plaque formation.

Pathway placement
Cascade stepLipid retention & oxidation
Confidencehigh
RationaleApoB-containing atherogenic lipoprotein; retained in intima driving atherosclerotic risk and MI.
Druggability
Not assessed (no mapped human gene target).

Assay & specimen

Specialized reference method
Specimen
Serum or plasma (EDTA)
Collection tube
K2/K3-EDTA (lavender-top) · Serum separator (gold/red-top, SST)
Method / principle
NMR lipoprotein particle analysis or density-gradient ultracentrifugation
Reagent / substrate
No chemical reagent — NMR spectral deconvolution of lipid methyl signals (or ultracentrifugal separation by density)
Platform
NMR (LabCorp NMR LipoProfile) / analytical ultracentrifuge
Turnaround · availability
Send-out · Specialized reference lab

Literature evidence(6)