Isocitric acid

metabolite

Isocitric acid downregulation in ACS reflects impaired aerobic metabolism and myocardial energy depletion during acute ischemia.

Pathway placement

Cascade stepMyocardial injury (shared endpoint)

Confidencemedium

RationaleTricarboxylic-acid-cycle intermediate; downregulated in ACS reflects myocardial energy deficit.

Also acts inSystemic / off-pathway

Druggability

Not assessed (no mapped human gene target).

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.

Specimen

Serum, plasma or urine

Collection tube

Serum separator (gold/red-top, SST) · Lithium heparin (green-top) · Sterile urine container

Method / principle

LC-MS/MS (targeted metabolomics) or enzymatic colorimetric where available

Reagent / substrate

Stable-isotope-labeled internal standard (MS); or enzyme-coupled Trinder reagent

Platform

LC-MS/MS; some automated chemistry

Turnaround · availability

Send-out / research · Specialized / research