L-Acetylcarnitine
metaboliteL-Acetylcarnitine dysregulation reflects impaired myocardial fatty-acid oxidation and energy depletion during STEMI.
Pathway placement
Cascade stepMyocardial injury (shared endpoint)
Confidencemedium
RationaleCarnitine metabolite; myocardial energy metabolism and ischemic stress marker.
Also acts inSystemic / off-pathway
Druggability
Not assessed (no mapped human gene target).
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum, plasma or urine
Collection tube
Serum separator (gold/red-top, SST) · Lithium heparin (green-top) · Sterile urine container
Method / principle
LC-MS/MS (targeted metabolomics) or enzymatic colorimetric where available
Reagent / substrate
Stable-isotope-labeled internal standard (MS); or enzyme-coupled Trinder reagent
Platform
LC-MS/MS; some automated chemistry
Turnaround · availability
Send-out / research · Specialized / research
Literature evidence(1)
- Metabolomics Analysis Identifies Differential Metabolites as Biomarkers for Acute Myocardial Infarction.Biomolecules · 2024 · PMID 38785939 · doi