large VLDL particles

lipoprotein

Large VLDL particles are ApoB-containing lipoproteins that accumulate in the arterial intima, undergo oxidation, and initiate atherosclerotic plaque formation and destabilization.

Pathway placement

Cascade stepLipid retention & oxidation

Confidencehigh

RationaleApoB-containing lipoprotein; retained subendothelially and oxidized, initiating atherogenesis.

Also acts inVascular inflammation

Druggability

Not assessed (no mapped human gene target).

Assay & specimen

Specialized reference method

Specimen

Serum or plasma (EDTA)

Collection tube

K2/K3-EDTA (lavender-top) · Serum separator (gold/red-top, SST)

Method / principle

NMR lipoprotein particle analysis or density-gradient ultracentrifugation

Reagent / substrate

No chemical reagent — NMR spectral deconvolution of lipid methyl signals (or ultracentrifugal separation by density)

Platform

NMR (LabCorp NMR LipoProfile) / analytical ultracentrifuge

Turnaround · availability

Send-out · Specialized reference lab

Literature evidence(1)

High-frequency metabolite profiling and the incidence of recurrent cardiac events in patients with post-acute coronary syndrome.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals · 2020 · PMID 32067501 · doi