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Lectin-like Oxidized LDL Receptor 1
Pathway / Lipid retention & oxidation

Lectin-like Oxidized LDL Receptor 1

protein

LOX-1 mediates uptake of oxidized LDL by endothelial cells and macrophages, fueling plaque lipid accumulation and inflammation.

Pathway placement
Cascade stepLipid retention & oxidation
Confidencehigh
RationaleLOX-1 is the key endothelial scavenger receptor for oxLDL; drives atherogenesis.
Also acts inVascular inflammation
Druggability
Not assessed (no mapped human gene target).

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)
Method / principle
Sandwich immunoassay (ELISA) — research-grade unless a cleared assay exists
Reagent / substrate
Matched anti-target antibody pair (capture + labeled detection)
Platform
ELISA microplate or multiplex (Luminex/MSD)
Turnaround · availability
Send-out / research · Research-grade (no universal clinical assay)

Literature evidence(22)