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leukotriene C4
Pathway / Plaque inflammation

leukotriene C4

metabolite

Leukotriene C4 is an eicosanoid inflammatory mediator released during leukocyte and platelet activation in ACS.

Pathway placement
Cascade stepPlaque inflammation
Confidencemedium
RationaleEicosanoid inflammatory mediator released by activated leukocytes and platelets.
Also acts inPlatelet activation
Druggability
Not assessed (no mapped human gene target).

Type I vs non-Type I discrimination

ScoresLow-confidence (proxy)
R — rupture / Type-I
35
C — non-Type-I
60
A — assay feasibility
42
E — evidence strength
24
T1DI (composite)
4
Specificity differential (R−C)-25.1
Non-Type-I axis panel
Does this marker also move in each non-Type-I setting? mag 0–3; higher means less Type-I-specific. n/a = no evidence retrieved, which is not the same as no change.
No non-Type-I axis evidence retrieved.
Tier: light (literature co-occurrence proxy — lower confidence). See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum, plasma or urine
Collection tube
Serum separator (gold/red-top, SST) · Lithium heparin (green-top) · Sterile urine container
Method / principle
LC-MS/MS (targeted metabolomics) or enzymatic colorimetric where available
Reagent / substrate
Stable-isotope-labeled internal standard (MS); or enzyme-coupled Trinder reagent
Platform
LC-MS/MS; some automated chemistry
Turnaround · availability
Send-out / research · Specialized / research

Literature evidence(1)