Linoleoyl carnitine (C18:2)
metaboliteIschemia-induced mitochondrial dysfunction generates acylcarnitine biomarkers of myocardial energy depletion.
Pathway placement
Cascade stepMyocardial injury (shared endpoint)
Confidencemedium
RationaleAcylcarnitine accumulation reflects mitochondrial β-oxidation stress during ischemia.
Also acts inLipid entry/oxidation
Druggability
Not assessed (no mapped human gene target).
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum, plasma or urine
Collection tube
Serum separator (gold/red-top, SST) · Lithium heparin (green-top) · Sterile urine container
Method / principle
LC-MS/MS (targeted metabolomics) or enzymatic colorimetric where available
Reagent / substrate
Stable-isotope-labeled internal standard (MS); or enzyme-coupled Trinder reagent
Platform
LC-MS/MS; some automated chemistry
Turnaround · availability
Send-out / research · Specialized / research
Literature evidence(2)
- GC-MS validation and analysis of targeted plasma metabolites related to carbonyl stress in type 2 diabetes mellitus patients with and without acute coronary syndrome.Biomedical chromatography : BMC · 2024 · PMID 38966927 · doi
- Pilot study of myocardial ischemia-induced metabolomic changes in emergency department patients undergoing stress testing.PloS one · 2019 · PMID 30707740 · doi