Lysoalkylphosphatidylcholine
lipidLysoalkylphosphatidylcholine is a pro-inflammatory lipid mediator in dense LDL promoting vascular inflammation.
Pathway placement
Cascade stepPlaque inflammation
Confidencemedium
RationaleEther-linked lysophospholipid; bioactive component of dense LDL.
Also acts inLipid entry/oxidation
Druggability
Not assessed (no mapped human gene target).
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum or plasma (EDTA to limit oxidation)
Collection tube
K2/K3-EDTA (lavender-top) · Serum separator (gold/red-top, SST)
Method / principle
LC-MS/MS lipidomics (targeted or shotgun)
Reagent / substrate
Deuterated lipid-class internal standards; MS/MS transitions
Platform
LC-MS/MS
Turnaround · availability
Research · Research-only
Literature evidence(1)
- LDL subclass lipidomics in atherogenic dyslipidemia: effect of statin therapy on bioactive lipids and dense LDL.Journal of lipid research · 2020 · PMID 32295829 · doi