Lysophosphatidylcholine O-18:1
lipidLysophosphatidylcholine O-18:1 is a lipid signature of fibrotic noncalcified coronary plaque phenotype relevant to rupture vulnerability.
Pathway placement
Cascade stepLipid retention & oxidation
Confidencehigh
RationaleLipid marker of fibrotic noncalcified plaque; associated with cap stability and rupture risk.
Also acts inCap degradation / rupture
Druggability
Not assessed (no mapped human gene target).
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum or plasma (EDTA to limit oxidation)
Collection tube
K2/K3-EDTA (lavender-top) · Serum separator (gold/red-top, SST)
Method / principle
LC-MS/MS lipidomics (targeted or shotgun)
Reagent / substrate
Deuterated lipid-class internal standards; MS/MS transitions
Platform
LC-MS/MS
Turnaround · availability
Research · Research-only
Literature evidence(1)
- Variability of the Plasma Lipidome and Subclinical Coronary Atherosclerosis.Arteriosclerosis, thrombosis, and vascular biology · 2021 · PMID 34809445 · doi