Malondialdehyde-modified LDL
lipoproteinMalondialdehyde-modified LDL is an oxidized ApoB-lipoprotein derivative driving plaque lipid-core accumulation and inflammatory macrophage recruitment.
Pathway placement
Cascade stepLipid retention & oxidation
Confidencehigh
RationaleOxidatively modified LDL; drives atherogenic lesion formation and immune activation.
Also acts inVascular inflammation
Druggability
Not assessed (no mapped human gene target).
Assay & specimen
Specialized reference method
Specimen
Serum or plasma (EDTA)
Collection tube
K2/K3-EDTA (lavender-top) · Serum separator (gold/red-top, SST)
Method / principle
Sandwich ELISA against the modified-apoB neoepitope
Reagent / substrate
Anti-modified-LDL monoclonal capture + anti-apoB detection
Platform
ELISA plate
Turnaround · availability
Research · Research/CE
Literature evidence(2)
- We Must Abandon the Myth: Oxidized Low-density Lipoprotein is not a Lipoprotein that Plays a Key Role in Atherogenesis.Current medicinal chemistry · 2025 · PMID 38494931 · doi
- Atherogenic Lipoproteins for the Statin Residual Cardiovascular Disease Risk.International journal of molecular sciences · 2022 · PMID 36362288 · doi