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MIF
Pathway / Plaque inflammation

MIF

protein

MIF drives atherosclerotic inflammation and thrombosis via macrophage recruitment and platelet activation in the acute coronary event.

Pathway placement
Cascade stepPlaque inflammation
Confidencemedium
RationalePleiotropic cytokine in atherosclerotic inflammation and macrophage-driven plaque formation.
Also acts inPlatelet activation
Druggability
Not assessed (no mapped human gene target).

Type I vs Type II discrimination

ScoresLow-confidence (proxy)
R — rupture / Type-I
52
C — confounder / Type-II
90
A — assay feasibility
68
E — evidence strength
33
T1DI (composite)
7
Specificity differential (R−C)-38.5
Confounder panel (Type-II drivers)
No confounder evidence retrieved.
Tier: light (literature co-occurrence proxy — lower confidence). See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)
Method / principle
Sandwich immunoassay (ELISA) — research-grade unless a cleared assay exists
Reagent / substrate
Matched anti-target antibody pair (capture + labeled detection)
Platform
ELISA microplate or multiplex (Luminex/MSD)
Turnaround · availability
Send-out / research · Research-grade (no universal clinical assay)

Literature evidence(6)