Minimally modified LDL

lipoprotein

Minimally modified LDL is a partially oxidized form that initiates endothelial dysfunction and early plaque inflammation.

Pathway placement

Cascade stepLipid retention & oxidation

Confidencehigh

RationaleEarly-stage LDL oxidation; triggers endothelial and inflammatory responses in atherogenesis.

Also acts inVascular inflammation

Druggability

Not assessed (no mapped human gene target).

Assay & specimen

Specialized reference method

Specimen

Serum or plasma (EDTA)

Collection tube

K2/K3-EDTA (lavender-top) · Serum separator (gold/red-top, SST)

Method / principle

Sandwich ELISA against the modified-apoB neoepitope

Reagent / substrate

Anti-modified-LDL monoclonal capture + anti-apoB detection

Platform

ELISA plate

Turnaround · availability

Research · Research/CE