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miR-1
Pathway / Myocardial injury (shared endpoint)

miR-1

rna

miR-1 is released from ischemic myocardium and dysregulated in MI; elevated levels indicate cardiomyocyte injury and arrhythmia risk.

Pathway placement
Cascade stepMyocardial injury (shared endpoint)
Confidencemedium
RationaleCardiac injury biomarker; dysregulated in AMI and ischemia-reperfusion; involved in arrhythmia and platelet activation.
Also acts inPlatelet activation
Druggability
Not assessed (no mapped human gene target).

Type I vs non-Type I discrimination

ScoresNon-Type-I-associated
R — rupture / Type-I
—
C — non-Type-I
67
A — assay feasibility
50
E — evidence strength
17
T1DI (composite)
2
Specificity differential (R−C)-51.7
Direct evidence: higher in non-Type I (D=0)
"miR-1 and miR-133a were correlated with cardiac necrosis protein markers and did not offer better discrimination" between T1MI and T2MI
Non-Type-I axis panel
Does this marker also move in each non-Type-I setting? mag 0–3; higher means less Type-I-specific. n/a = no evidence retrieved, which is not the same as no change.
2sepsis / systemic inflammationn/a
2anemia / acute blood lossn/a
2hypovolemia / dehydrationn/a
2tachyarrhythmiamag 2
2hypoxemia / respiratory failuren/a
2hypertensive emergencymag 2
2high-demand / peri-operative stressn/a
3sudden cardiac deathmag 2
4aPCI-related periproceduralmag 3
4bstent thrombosisn/a
4cin-stent restenosismag 1
5CABG-relatedmag 2
Coverage: 6/12 axes with evidence
Tier: deep-scored (abstract-extracted) · 14 supporting references. See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Whole blood or cell-free plasma
Collection tube
PAXgene/Tempus RNA tube · K2/K3-EDTA (lavender-top)
Method / principle
RT-qPCR (TaqMan) or small-RNA sequencing
Reagent / substrate
Target-specific primers/probe; reverse transcriptase (miRNA: stem-loop RT primer)
Platform
qPCR instrument / NGS
Turnaround · availability
Research / send-out · Research (few LDTs)

Literature evidence(6)