miR-1307-5p
rnamiRNA marking plaque inflammation and vascular dysfunction in acute coronary syndrome.
Pathway placement
Cascade stepPlaque inflammation
Confidencemedium
RationaleEarly ACS diagnostic marker; reflects inflammatory/endothelial activation in acute event.
Also acts inEndothelial activation/erosion
Druggability
Not assessed (no mapped human gene target).
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Whole blood or cell-free plasma
Collection tube
PAXgene/Tempus RNA tube · K2/K3-EDTA (lavender-top)
Method / principle
RT-qPCR (TaqMan) or small-RNA sequencing
Reagent / substrate
Target-specific primers/probe; reverse transcriptase (miRNA: stem-loop RT primer)
Platform
qPCR instrument / NGS
Turnaround · availability
Research / send-out · Research (few LDTs)
Literature evidence(1)
- miR-1307-5p mediates endothelial dysfunction and inflammation induced by acute coronary syndrome by targeting PIM3.Journal of cardiothoracic surgery · 2026 · PMID 42106777 · doi