miR-15a-5p
rnamiR-15a-5p serves as a STEMI diagnostic biomarker with regulatory roles in endothelial cell inflammation.
Pathway placement
Cascade stepPlaque inflammation
Confidencemedium
RationaleSTEMI diagnostic miRNA with endothelial regulatory role; PAX8-AS1-regulated.
Also acts inEndothelial activation/erosion
Druggability
Not assessed (no mapped human gene target).
Type I vs Type II discrimination
ScoresLow-confidence (proxy)
R — rupture / Type-I23
C — confounder / Type-II47
A — assay feasibility50
E — evidence strength18
T1DI (composite)3
Specificity differential (R−C)-23.3
Confounder panel (Type-II drivers)
No confounder evidence retrieved.
Tier: light (literature co-occurrence proxy — lower confidence). See the discrimination table for all markers.
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Whole blood or cell-free plasma
Collection tube
PAXgene/Tempus RNA tube · K2/K3-EDTA (lavender-top)
Method / principle
RT-qPCR (TaqMan) or small-RNA sequencing
Reagent / substrate
Target-specific primers/probe; reverse transcriptase (miRNA: stem-loop RT primer)
Platform
qPCR instrument / NGS
Turnaround · availability
Research / send-out · Research (few LDTs)
Literature evidence(2)
- lncRNA PAX8-AS1 Serves as a Diagnostic Biomarker for Acute Coronary Syndrome and Predicts the Occurrence of Major Adverse Cardiovascular Events after Percutaneous Coronary Intervention.The Tohoku journal of experimental medicine · 2025 · PMID 39880645 · doi
- Circulating MicroRNAs in Young Patients with Acute Coronary Syndrome.International journal of molecular sciences · 2018 · PMID 29762500 · doi