miR-18a-3p
rnaCirculating microRNA regulating inflammatory and lipid-metabolic gene networks dysregulated in coronary artery disease.
Pathway placement
Cascade stepPlaque inflammation
Confidencemedium
RationalemicroRNA downregulation in CAD modulates cardiovascular pathogenic genes.
Also acts inLipid entry/oxidation
Druggability
Not assessed (no mapped human gene target).
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Whole blood or cell-free plasma
Collection tube
PAXgene/Tempus RNA tube · K2/K3-EDTA (lavender-top)
Method / principle
RT-qPCR (TaqMan) or small-RNA sequencing
Reagent / substrate
Target-specific primers/probe; reverse transcriptase (miRNA: stem-loop RT primer)
Platform
qPCR instrument / NGS
Turnaround · availability
Research / send-out · Research (few LDTs)
Literature evidence(1)
- Levels of miR-130b-5p in peripheral blood are associated with severity of coronary artery disease.Molecular biology reports · 2021 · PMID 34689283 · doi