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miR-21-5p
Pathway / Plaque inflammation

miR-21-5p

rna

miR-21-5p is an acute MI biomarker that regulates antioxidant responses (SOD2) and vascular inflammation.

Pathway placement
Cascade stepPlaque inflammation
Confidencehigh
RationaleMI biomarker regulating SOD2; vascular performance and heart failure regulatory network.
Also acts inMyocardial injury
Druggability
Not assessed (no mapped human gene target).

Type I vs Type II discrimination

ScoresLow-confidence (proxy)
R — rupture / Type-I
32
C — confounder / Type-II
62
A — assay feasibility
50
E — evidence strength
23
T1DI (composite)
4
Specificity differential (R−C)-30.3
Confounder panel (Type-II drivers)
No confounder evidence retrieved.
Tier: light (literature co-occurrence proxy — lower confidence). See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Whole blood or cell-free plasma
Collection tube
PAXgene/Tempus RNA tube · K2/K3-EDTA (lavender-top)
Method / principle
RT-qPCR (TaqMan) or small-RNA sequencing
Reagent / substrate
Target-specific primers/probe; reverse transcriptase (miRNA: stem-loop RT primer)
Platform
qPCR instrument / NGS
Turnaround · availability
Research / send-out · Research (few LDTs)

Literature evidence(4)