miR-3667-3p
rnamiR-3667-3p differentially marks the endothelial erosion phenotype in Type 1 MI, distinguishing erosion-mediated acute coronary thrombosis from plaque rupture.
Pathway placement
Cascade stepEndothelial activation & erosion
Confidencemedium
RationaleDiscriminates plaque erosion (endothelial-driven) phenotype in STEMI.
Druggability
Not assessed (no mapped human gene target).
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Whole blood or cell-free plasma
Collection tube
PAXgene/Tempus RNA tube · K2/K3-EDTA (lavender-top)
Method / principle
RT-qPCR (TaqMan) or small-RNA sequencing
Reagent / substrate
Target-specific primers/probe; reverse transcriptase (miRNA: stem-loop RT primer)
Platform
qPCR instrument / NGS
Turnaround · availability
Research / send-out · Research (few LDTs)
Literature evidence(1)
- High Levels of Circulating MicroRNA-3667-3p Are Associated with Coronary Plaque Erosion in Patients with ST-Segment Elevation Myocardial Infarction.International heart journal · 2019 · PMID 31484870 · doi