Pathway / Endothelial activation & erosion

miR-377

rna

miR-377 is dysregulated during acute MI, modulating endothelial function and injury responses; elevated levels mark endothelial damage and dysfunction.

Pathway placement

Cascade stepEndothelial activation & erosion

Confidencemedium

RationaleDiagnostic marker and regulator of endothelial injury in MI.

Also acts inVascular inflammation

Druggability

Not assessed (no mapped human gene target).

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.

Specimen

Whole blood or cell-free plasma

Collection tube

PAXgene/Tempus RNA tube · K2/K3-EDTA (lavender-top)

Method / principle

RT-qPCR (TaqMan) or small-RNA sequencing

Reagent / substrate

Target-specific primers/probe; reverse transcriptase (miRNA: stem-loop RT primer)

Platform

qPCR instrument / NGS

Turnaround · availability

Research / send-out · Research (few LDTs)

Literature evidence(1)

Serum miR-377 Can Be Used as a Diagnostic Marker for Acute Coronary Syndrome and Can Regulate Proinflammatory Factors and Endothelial Injury Markers.
Acta medica Okayama · 2022 · PMID 36549775 · doi