miR-484
rnamiR-484 is acutely elevated during acute myocardial infarction and serves as a diagnostic biomarker for acute coronary events.
Pathway placement
Cascade stepMyocardial injury (shared endpoint)
Confidencemedium
RationaleElevated in acute coronary syndrome; acute cardiomyocyte injury marker.
Druggability
Not assessed (no mapped human gene target).
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Whole blood or cell-free plasma
Collection tube
PAXgene/Tempus RNA tube · K2/K3-EDTA (lavender-top)
Method / principle
RT-qPCR (TaqMan) or small-RNA sequencing
Reagent / substrate
Target-specific primers/probe; reverse transcriptase (miRNA: stem-loop RT primer)
Platform
qPCR instrument / NGS
Turnaround · availability
Research / send-out · Research (few LDTs)
Literature evidence(2)
- Platelet MicroRNA-484 as a Novel Diagnostic Biomarker for Acute Coronary Syndrome.Laboratory medicine · 2023 · PMID 36214592 · doi
- A MicroRNA Signature in Acute Coronary Syndrome Patients and Modulation by Colchicine.Journal of cardiovascular pharmacology and therapeutics · 2020 · PMID 32356454 · doi