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natriuretic peptides
Pathway / Off-pathway / systemic markers

natriuretic peptides

peptide

Natriuretic peptides are released by stressed ventricular myocardium post-infarction, indicating ventricular remodeling and hemodynamic compromise.

Pathway placement
Cascade stepOff-pathway / systemic markers
Confidencehigh
RationaleMyocyte stretch marker; reflect post-MI cardiac dysfunction and heart-failure risk.
Druggability
Not assessed (no mapped human gene target).

Type I vs non-Type I discrimination

ScoresNon-Type-I-associated
R — rupture / Type-I
—
C — non-Type-I
67
A — assay feasibility
66
E — evidence strength
30
T1DI (composite)
4
Specificity differential (R−C)-63.7
Direct evidence: higher in non-Type I (D=-1)
NT-proBNP: 10,327 +/- 12,923 ng/L in T2-MI vs 4675 +/- 11,740 ng/L in T1-MI (P=0.006); a second cohort found no T1/T2 discrimination
Non-Type-I axis panel
Does this marker also move in each non-Type-I setting? mag 0–3; higher means less Type-I-specific. n/a = no evidence retrieved, which is not the same as no change.
2sepsis / systemic inflammationn/a
2anemia / acute blood lossn/a
2hypovolemia / dehydrationn/a
2tachyarrhythmian/a
2hypoxemia / respiratory failuren/a
2hypertensive emergencyn/a
2high-demand / peri-operative stressn/a
3sudden cardiac deathmag 2
4aPCI-related periproceduraln/a
4bstent thrombosisn/a
4cin-stent restenosismag 2
5CABG-relatedmag 2
Coverage: 3/12 axes with evidence
Tier: deep-scored (abstract-extracted) · 6 supporting references. See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Plasma (EDTA; peptidase-labile — chilled + protease inhibitor)
Collection tube
K2-EDTA, chilled plastic (lavender-top) · Serum separator (gold/red-top, SST)
Method / principle
Competitive/sandwich immunoassay or LC-MS/MS
Reagent / substrate
Anti-peptide antibody; or isotope-labeled internal standard (MS)
Platform
Immunoassay / LC-MS/MS
Turnaround · availability
Send-out / research · Research-grade

Literature evidence(7)